| 中文名 | 布帕伐醌 |
| 英文名 | Buparvaquone |
| 别名 | 布帕伐琨 布帕伐醌 单晶冰糖 BUPARVAQUONE 布帕伐醌 2-[(4-叔丁基环己基)甲基]-3-羟基-1,4-萘二酮 2-((4-(叔丁基)环己基)甲基)-3-羟基萘-1,4-二酮 |
| 英文别名 | BW-720C CS-1178 butalex Buparvaquone Buparvaquone-d4 2-((4-tert-butylcyclohexyl)methyl)-3-hydroxy-1,4-naphthoquinone 2-((4-tert-butylcyclohexyl)Methyl)-3-hydroxynaphthalene-1,4-dione 2-[(4-tert-butylcyclohexyl)methyl]-3-hydroxynaphthalene-1,4-dione 3-[(4-tert-butylcyclohexyl)methyl]-4-hydroxynaphthalene-1,2-dione 2-((4-(1,1-dimethylethyl)cyclohexyl)methyl)-3-hydroxy-4-naphthalenedione 2-[[4-(1,1-dimethylethyl)cyclohexyl]methyl]-3-hydroxy-1,4-naphthalenedione |
| CAS | 88426-33-9 |
| EINECS | 618-162-1 |
| 化学式 | C21H26O3 |
| 分子量 | 326.43 |
| InChI | InChI=1/C21H26O3/c1-21(2,3)14-10-8-13(9-11-14)12-17-18(22)15-6-4-5-7-16(15)19(23)20(17)24/h4-7,13-14,24H,8-12H2,1-3H3 |
| 密度 | 1.158±0.06 g/cm3(Predicted) |
| 熔点 | 178-184°C |
| 沸点 | 460.7±45.0 °C(Predicted) |
| 闪点 | 246.536°C |
| 蒸汽压 | 0mmHg at 25°C |
| 溶解度 | DMSO: soluble |
| 折射率 | 1.574 |
| 酸度系数 | 5.04±0.10(Predicted) |
| 存储条件 | Sealed in dry,2-8°C |
| 外观 | powder |
| 颜色 | Yellow |
| 体外研究 | In 4-day proliferation assays, buparvaquone efficiently inhibitsN. caninum tachyzoite replication(IC 50 =4.9 nM; IC 100 =100 nM).Buparvaquone is significantly selective against L. (L.) infantumchagasi intracellular amastigotes, with an IC 50 value of 1.5 μM.Other cutaneous species are also susceptible to buparvaquone, withIC 50 values in the range 1-4 μM. |
| 体内研究 | Buparvaquone具有较长的血浆半衰期（至少7天）和低毒性作用（在大鼠中口服LD50大于8000 mg/kg）。 |
