中文名 | Firocoxib |
英文名 | Firocoxib |
别名 | 非罗考昔 非罗考昔溶液, 100PPM 3-(环丙基甲氧基)-5,5-二甲基-4-[4-(甲基磺酰基)苯基]-2(5H)-呋喃酮 |
英文别名 | Equixx Librens Equioxx FIROCOXIB Firocoxib ML 1785713 3-(cyclopropylmethoxy)-5,5-dimethyl-4-(4-methylsulfonylphenyl)furan-2-one 2(5H)-Furanone,3-(cyclopropylmethoxy)-5,5-dimethyl-4-4-(methylsulfonyl)phenyl- 3-(Cyclopropylmethoxy)-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone |
CAS | 189954-96-9 |
EINECS | 200-001-2 |
化学式 | C17H20O5S |
分子量 | 336.4 |
密度 | 1.31 |
熔点 | 78-80°C |
沸点 | 563.9±50.0 °C(Predicted) |
溶解度 | 氯仿 (微溶) 、乙酸乙酯 (微溶) 、甲醇 (微溶) |
存储条件 | Sealed in dry,Store in freezer, under -20°C |
外观 | 固体 |
颜色 | White to Off-White |
体外研究 | The COX-1:COX-2 selectivity ratios generally are established bycomparing the IC 50 for COX-1 to the IC 50 for COX-2. The IC 80value more closely resembles the steady-state plasma drugconcentration than does the IC 50 value.The selectivity ratio forFirocoxib based on the IC 80 values is 121 (IC 80 of 0.36 μM and43.6 μM for COX-2 and COX-1, respectively), indicating thatselectivity for COX-2 is not reduced at concentrations higher thanthe IC 50 . Notably, Firocoxib concentrations that yield 80% to 95%inhibition of COX-2 produce < 20% inhibition of COX-1. |
盐酸奈必洛尔原料-多肽GLP-1原料-睾酮激素甾体-南京辰瑞晟生物医药科技公司,
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