| 中文名 | 阿伐那非 |
| 英文名 | Avanafil |
| 别名 | 阿伐那非 阿法那非 艾瓦那非 阿瓦那非 发阿伐那非 天然提取物发阿伐那非 阿伐那非330784-47-9|优质阿伐那非 4-[(3-氯-4-甲氧基苄基)氨基]-2-[2-(羟甲基)-1-吡咯烷基]-N-(2-嘧啶基甲基)-5-嘧啶甲磺酰胺 |
| 英文别名 | vanafil avanfil Avanafil Avanafil PDE5 inhibitor (S)-4-((3-Chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-yl (S)-2-(2-Hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylamino)-5-[(2-pyrimidinylmethyl)carbamoyl]pyrimidine 4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide 4-((3-chloro-4-Methoxybenzyl)aMino)-2-(2-(hydroxyMethyl)pyrrolidin-1-yl)-N-(pyriMidin-2-ylMethyl)pyriMidine-5-carboxaMide (S)-4-((3-Chloro-4-Methoxybenzyl)aMino)-2-(2-(hydroxyMethyl)pyrrolidin-1-yl)-N-(pyriMidin-2-ylMethyl)pyriMidine-5-carboxaMide 4-[(3-chloro-4-methoxybenzyl)amino]-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide Avanafil4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide 4-[[(3-Chloro-4-Methoxyphenyl)Methyl]aMino]-2-[(2S)-2-(hydroxyMethyl)-1-pyrrolidinyl]-N-(2-pyriMidinylMethyl)-5-pyriMidinecarboxaMide |
| CAS | 330784-47-9 |
| EINECS | 000-000-0 |
| 化学式 | C23H26ClN7O3 |
| 分子量 | 483.95 |
| InChI | InChI=1/C23H26ClN7O3/c1-34-19-6-5-15(10-18(19)24)11-27-21-17(22(33)28-13-20-25-7-3-8-26-20)12-29-23(30-21)31-9-2-4-16(31)14-32/h3,5-8,10,12,16,32H,2,4,9,11,13-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m0/s1 |
| 密度 | 1.372 |
| 熔点 | 150-152°C |
| 溶解度 | DMSO (微溶)，甲醇 (微溶，加热) |
| 折射率 | 1.651 |
| 酸度系数 | 11.84±0.46(Predicted) |
| 存储条件 | Sealed in dry,Store in freezer, under -20°C |
| 外观 | 固体 |
| 颜色 | White to Off-White |
| 体内研究 | Avanafil (静脉注射)促进阴茎勃起，在狗体内的ED200%为37.5微克/千克。Avanafil的十二指肠内治疗增强盆神经刺激诱导的阴茎海绵体内压和持续时间。 Avanafil(1μM)在T2DM大鼠海绵体内的注射会使勃起反应局部改善。 |
| 海关编号 | 29339900 |
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