| 中文名 | P物质 |
| 英文名 | SUBSTANCE P |
| 别名 | 神经肽 P物质 物质 P 多肽物质P 神经肽H-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2 |
| 英文别名 | SUBSTANCE P SUBSTANCE P BOVINE SUBSTANCE P (HUMAN, BOVINE, RAT, MOUSE) SUBSTANCE P, [D-ARG1, D-PRO2, D-TRP7,9, LEU11] ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2 H2N-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET H-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2 (2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,5-dioxopentan-2-yl]pentanediamide |
| CAS | 33507-63-0 |
| EINECS | 251-545-8 |
| 化学式 | C63H98N18O13S |
| 分子量 | 1347.63 |
| 密度 | 1.42±0.1 g/cm3(Predicted) |
| 熔点 | 148 °C |
| 水溶性 | Soluble in water, DMSO, and Acetic Acid. |
| 溶解度 | H2O: 1 mg/mL |
| 酸度系数 | 13.26±0.46(Predicted) |
| 存储条件 | −20°C |
| 外观 | 粉末 |
| 颜色 | white |
| 物化性质 | 白色冷冻干燥粉末，易溶于水，高纯度的水溶液极易失活，加入吐温80、明胶、人血浆白蛋白或牛丙种球蛋白可增加其稳定性；pH大于8时不稳定，遇胃蛋白酶和胰凝乳蛋白酶失活；宜保存于低pH值中，并充氮气或加入抗氧化剂以避免其失活。 |
| 体外研究 | The neuropeptide substance P (SP) that are mediated by theneurokinin 1 receptor (NK1-R) desensitize and resensitize, whichmay be associated with NK1-R endocytosis and recycling. SP and theNK1-R are internalized into the same clathrin immunoreactivevesicles, and then sorted into different compartments. SP is intactat the cell surface and in early endosomes, but slowly degraded inperinuclear vesicles. SP induces clathrin-dependent internalizationof the NK1-R. The SP/NK1-R complex dissociates in acidifiedendosomes. SP is degraded, whereas the NK1-R recycles to the cellsurface. SP induces internalization of the NK1-R both intransfected epithelial cells. |
盐酸奈必洛尔原料-多肽GLP-1原料-睾酮激素甾体-南京辰瑞晟生物医药科技公司，
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