| 中文名 | 醋酸艾塞那肽 |
| 英文名 | Exenatide acetate |
| 别名 | 依克那肽 醋酸恩夫韦地 乙酸艾塞那肽 醋酸艾塞那肽 艾塞那肽杂质 艾塞那肽醋酸盐 醋酸艾塞那肽 141732-76-5 醋酸艾塞那肽 EXENATIDEACETATE |
| 英文别名 | Exenatide Extendin-4 ExenatideAcetate Exenatide acetate EXENATIDE ACETATE Exenatide Acettate ENFUVIRTIDE ACETATE enfuvirtide acetate EXENATIDE ACETATE(EXENDIN-4) His-Gly-Gly-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH{2} His-Gly-Gly-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 |
| CAS | 141732-76-5 |
| EINECS | 1592732-453-0 |
| 化学式 | C186H286N50O62S |
| 分子量 | 4244.60796 |
| 熔点 | >209°C (dec.) |
| 溶解度 | 乙腈 (微溶)，水 (微溶) |
| 存储条件 | Refrigerator, under inert atmosphere |
| 外观 | 固体 |
| 颜色 | White to Off-White |
| 物化性质 | 白色粉末，可溶于甲醇、乙醇、DMSO等有机溶剂。 |
| 体外研究 | A cell-cell fusion assay reveals that the effective concentrationfor achieving 50% inhibition (IC 50 ) of Enfuvirtide is 23 ± 6 nM.IFN-λs (1, 2, or 3) or the antiretrovirals (AZT, Efavirenz,Indinavir, and Enfuvirtide) significantly inhibita the expressionof HIV p24 antigen and Gag gene in macrophages. IFN-λs (1, 2, or 3)also enhanced the anti-HIV (Bal) effect of AZT, Efavirenz,Indinavir, and Enfuvirtide. |
| 体内研究 | Enfuvirtide has a T 1/2 of 3.8 h. |
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