| 中文名 | 罗西酮盐酸盐 |
| 英文名 | (3aR,4S,7R,7aS)-2-[(1R,2R)-2-[4-(1,2-Benzisothiazol-3-yl)piperazin-1-ylmethyl]cyclohexylmethyl]hexahydro-1H-4,7-methanoisoindole-1,3-dionehydrochloride |
| 别名 | 盐酸鲁拉西酮 盐酸卢拉西酮 罗西酮盐酸盐 鲁拉西酮盐酸盐 外二烯卢拉西酮 罗拉西酮盐酸盐 盐酸鲁拉西酮(罗西酮盐酸盐) 盐酸鲁拉西酮-罗拉西酮盐酸盐 盐酸卢拉西酮LURASIDONHYDROCHLORIDE |
| 英文别名 | LurasidoneHCl ExodieneLurasidone Lurasidonhydrochlorid Lurasidonhydrochloride LurasidoneHydrochloride Lurasidonehydrochloride Lurasidone Hydrochloride Tablets (3aR,4R,7S,7aS)-2-(((1R,2R)-2-((4-(benzo[d]isothiazol-3-yl) (3aR,4S,7R,7aS)-2-[(1R,2R)-2-[4-(1,2-Benzisothiazol-3-yl)piperazin-1-ylmethyl]cyclohexylmethyl]hexahydro-1H-4,7-methanoisoindole-1,3-dionehydrochloride (3aR,4S,7R,7aS)-2-(((1R,2R)-2-((4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)methyl)cyclohexyl)methyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dionehydrochloride (3aR,4S,7R,7aS)-2-[[(1R,2R)-2-[[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]methyl]cyclohexyl]methyl]hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dionehydrochloride 4,7-Methano-1H-isoindole-1,3(2H)-dione,2-[[(1R,2R)-2-[[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]methyl]cyclohexyl]methyl]hexahydro-,(3aR,4S,7R,7aS)- hydrochloride |
| CAS | 367514-88-3 |
| EINECS | 682-423-6 |
| 化学式 | C28H36N4O2S |
| 分子量 | 492.684 |
| InChIKey | PJIBDQSA-N |
| 熔点 | 198-205°C |
| 闪点 | 9℃ |
| 存储条件 | Refrigerator |
| 体外研究 | Lurasidone剂量依赖性拮抗多巴胺刺激的人多巴胺D2L受体上[35S]GTPγS结合，KB 值为2.8nM。Lurasidone拮抗CHO/h5-HT7细胞中5-HT刺激的cAMP积累，KB值为2.6nM。Lurasidone部分刺激[35S]GTPγS结合到人5-HT1A受体的膜制剂上，Zui大作用为33%。Lurasidone剂量依赖性增加大鼠额叶皮层和纹状体中DOPAC/多巴胺比率。 |
